Patrick S. Hamilton

Education

University of Wisconsin-Madison Ph.D. 1989 Electrical Engineering
University of Wisconsin-Madison M.S. 1985 Biomedical Eng.
Massachusetts Institute of Technology B.S. 1981 Electrical Engineering

Professional Experience

1995-  Founding Partner, EP Limited, Cambridge, MA.
1991-95  Lafayette College, Easton, Pennsylvania, Asst. Prof., Dept. of Elec. Eng.
1989-91 Bucknell University, Lewisburg, Pennsylvania, Visiting Asst. Prof., Dept. of Elec. Eng.
1988-89 Burdick Corporation, Milton, Wisconsin, Research Engineer.
1982-83 MIT Lab for Medical Ultrasonics, Cambridge, Massachusetts. Staff Engineer.
1981-82 Analogic Corporation, Wakefield, Massachusetts, Design Engineer.

Software Experience

Experienced in PIC, Motorola, and Intel assembly language programming and C language programming on multiple platforms and embedded systems. QRS detection, VF/VT detection, and ECG compression software (written in C) now running in a number of commercial systems. 

Consulting Experience

2004- Analogic Corp. Peabody, MA.  ECG analysis.
1999 Cadent Medical Corp. Bedford, MA.  ECG data compression.
1997-98  Tectrix Inc., Irvine CA, Consulting on exercise equipment heartrate detector hardware and software design.
1997 Venable, Baetjer, & Howard, LLP, Baltimore, MD. Consulting on hardware and software for patent litigation related to a biomedical product. 
1993- Braemar, Burnsville, Minnesota. Consulting on ECG data compression. 
1993 Ohmeda, Louisville, Colorado. Consulting on ECG analysis. 
1993 Gensia Pharmaceuticals, Inc., San Diego, California. Consulting on ECG analysis.
1991 Critikon Corp., Tampa, Florida. Consulting on ECG analysis. 
1989-92  Burdick Corp., Milton, Wisconsin. Consulting on ECG data compression and analysis. 
1986-88  HEM Data Corp., Southfield, Michigan. Developed software for signal processing.
1986-87 Cardiac Evaluation Center, Inc., Milwaukee, Wisconsin. Consulting on ECG analysis.
1987 Lifecore, Inc., Pittsburgh, Pennsylvania. Consulting on ECG analysis. 

Publications

Hamilton PS, Chow C, Guerrero JL, Supple G, Silver LP, Aimi R, Sullivan S, Levine RA, Curley MG (2002), "Artifact reduction for continuous thermodilution measurement of cardiac output," Proceedings of the Second Joint EMBS/BMES Conference, pp 1754-1755.
Curley MG, Silver LP, Ni AC, Walsh JT, and Hamilton PS (2002), “First Ex Vivo Tests Of A New Method To Ablate Ventricular Tachycardia,” Cardiostim Conference, Nice, Fr.
Curley MG and Hamilton PS (2001), “Use of saline injection to create large thermal lesions during radio frequency ablation therapy: 2. Finite Difference Model.” Annual Congress of the American Society for Mechanical Engineers, New York, November 2001.
Silver LP, Hamilton PS, Ni AC, Aimi RM, and Curley MG (2001), “Use of saline injection to create large thermal lesions during radio frequency ablation therapy: 2. Experimental results.” Annual Congress of the American Society for Mechanical Engineers, New York, November 2001.
Silver LP, Hamilton PS, and Curley MG (2001), “Comparison of silver/silver-chloride, platinum, and stainless steel as materials for radio-frequency ablations.” Annual Congress of the American Society for Mechanical Engineers, New York, November 2001.
Silver LP, Hamilton PS, Ni AC, Aimi RM, and Curley MG (2001), “Large volume ventricular ablations made ex vivo with a saline-enhanced radio frequency catheter.” Annual Meeting of the North American Society for Pacing and Electrophysiology, Boston, May 2001.
Hamilton, P.S., Curley, M.G., Aimi, R.M., Sae-Hau, C.,  (2000), "Comparison of methods for adaptive removal of motion artifact," Computers in Cardiology 2000; 27:383-386. 
Hamilton, P.S., Curley, M.G., Aimi, R.M., (2000), "Levenberg-Marquardt Estimation for Accurate and Efficient Continuous Measurement of Cardiac Output," Proceedings of the 22nd Annual Conf. IEEE Eng. Med. Biol. Soc.,  Paper WE-E203-03.
Hamilton, P.S., Curley, M.G., Aimi, R.M., (1999), "Effect of Adaptive Motion Artifact Reduction on QRS Detection," presented at AAMI 1999 Annual Meeting, submitted to Biomedical Instrumentation & Technology.
Hamilton, P.S., M.G. Curley, (1997), "Adaptive Removal of Motion Artifact," Proceedings of the 19th Annual Conf. IEEE Eng. Med. Biol. Soc., pp 297-299.
Curley, M.G., P.S. Hamilton, (1997), "Creation of Large Thermal Lesions in Liver using Saline-Enhanced RF Ablation," submitted to the Proceedings of the 19th Annual Conf. IEEE Eng. Med. Biol. Soc., pp 2516-2519.
Hamilton, P.S., M.G. Curley (1997), "An Adaptive System for Reduction of ECG Motion Artifact," Proc. 32nd Annual Meeting of the AAMI, Washington.
Curley, M.G., P.S. Hamilton, J.T. Walsh, C.Rappaport, Z. Gu, W. Newman (1997), "Investigation of Volumetric Heating Methods for Cardiac Output Measurement," Proc. 32nd Annual Meeting of the AAMI, Washington.
Curley, M.G., Hamilton, P.S., Walsh, J.T., (1997) "Measurement of Cardiac Output using Near-Infrared Heating of Blood," presented at SPIE BIOS ‘97, San Jose, CA.
Hamilton, P.S., Curley, M.G, "Measurement of Coronary Artery Blockages Using Moderate Frequency Pressure," 18thAnnual Conf. IEEE Eng. Med. Biol. Soc.
Curley, M.G., Hamilton, P.S., Walsh, J.T., Rappaport, C.M., Gu, Z., Newman, W.H., "An Evaluation of Methods for Measuring Cardiac Output with Volumetric Heating," 18th Annual Conf. IEEE Eng. Med. Biol. Soc.
Hamilton, P.S., "A Comparison of Adaptive and Nonadaptive Filters for Reduction of Power Line Interference in the ECG," IEEE Trans. Biomed Eng., BME-43, pp. 105-109, January 1996.
Hamilton, P.S., "60 Hz filtering for ECG signals: To adapt or not to adapt?", Proc. 15th Annual Conf. IEEE Eng. Med. Biol. Soc., pp. 778-780, 1993.
Hamilton, P.S., "Adaptive Compression of the Ambulatory Electrocardiogram," Biomedical Instrumentation & Technology, v. 27, #1, pp. 56-63, Jan.- Feb. 1993.
Hamilton, P.S., "A comparison of algorithms for ambulatory ECG compression with fixed average data rate," in Proc. Computers in Cardiology 1992, Los Alamitos, CA.: IEEE Computer Society Press, pp. 683-686, 1992.
Hamilton, P.S., Tompkins, W.J., "Compression of the ambulatory ECG by average beat subtraction and residual differencing," IEEE Trans. Biomed. Eng., BME-38:253-9, March 1991.
Hamilton, P.S., Tompkins, W.J., "A comparison of theoretical and experimental rate distortion performance in compression of ambulatory ECGs," IEEE Transactions on Biomedical Engineering, BME-38, pp. 260-266, March 1991.
Hamilton, P.S., Tompkins, W.J., "Estimation of rate distortion bounds for compression ambulatory ECGs," Proc. 11th Annual Conf. IEEE Eng. Med. Biol. Soc., 1989.
Hamilton, P.S., Tompkins, W.J., "Adaptive matched filtering for QRS detection," Proc. 10th Annual Conf. IEEE Eng. Med. Biol. Soc., 1988.
Hamilton, P.S. "GPIB (IEEE 488) interfacing," In Interfacing Sensors to the IBM PC. W. J. Tompkins and J. G. Webster (eds.). Englewood Cliffs, NJ: Prentice Hall, pp. 161-173, 1988.
Hamilton, P.S., and Tompkins, W.J. "Detection of ventricular fibrillation and tachycardia by adaptive modeling," Proc. 9th Annual Conf. IEEE Eng. Med. Biol. Soc., pp. 1881-1882, 1987.
Hamilton, P.S., and Tompkins, W.J. "Quantitative investigation of QRS Detection Rules using the MIT/BIH Arrhythmia Database", IEEE Trans. Biomed Eng., BME-33 (12), pp. 1157-65, 1986.
Hamilton, P.S., and Tompkins, W.J. "Adaptive RR interval prediction," Proc. 8th Annual Conf. of the IEEE Eng. Med. Biol. Soc., pp. 284-287, 1986.

Patents

"Apparatus and method for reduction of motion artifact," U.S. Patent number 5,978,693.
"Thermal Ablation System," U.S. Patent number 6,328,735 
1 U.S. Patent pending.

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